Bacterial Cytotoxicity and Induction of Apoptosis in Promyeloctic (Line HL-60) Cells by Novel Organotellurium Compounds

B. L. Sailer%, T. Prow%, S. Dickerson%, J. Watson%, N. Liles%, S. J. Patel#, V. Van Fleet-Stalder#, and T. G. Chasteen#

#Department of Chemistry, Sam Houston State University, Huntsville, Texas, 77341-2117
%Department of Biological Sciences, Sam Houston State University, Huntsville, Texas, 77341-2117

Environmental Toxicology and Chemistry, 1999, 18, 2926-2933. ET&C abstract


Summary of work

Joint work carried out in two research groups has resulted in an examination of the relative toxicity of two organotellurium compounds, both synthgesized by Dr. Thomas Junk, LSU Baton Rouge. These two compounds, 3,3',4,4',-tetrachlorodiphenyl ditelluride (ditelluride) and telluranthrene. Growth rate inhibition experiments using a strain of Pseudomonas fluorescens (K27, isolated by Dr. Ray Fall, University of Colorado, Boulder) showed that these molecules are comparable in toxicity to the invironmentally important selenium oxyanions, selenate and selenite.

Work with human promyelocytic cells indicate that both compounds induced apoptosis, so-called programmed cell death. Apoptotic induction was does and time dependent as monitored by three different analytical methods: fluorescence microscopy, flow cytometry, and gel electrophoresis.

Like some organoselenium compounds, use of organotellurium compounds may be applicable in chemoprevention and cancer theatment.


Back to Chasteen's Research Group Publications

On to the Chemiluminescence Home Page