My research interests focus on studying how motility is regulated in eukaryotic cilia and flagella. These motility organelles have a core structure known as the axoneme that controls movement. My research focuses on characterizing signal transduction molecules that are present in the axoneme, and understanding how these molecules interact to produce movement. Chlamydomonas , a bi-flagellated protist, is used as a model organism for these studies. This research is important to better understand human diseases such as Kartagener's syndrome, a disease associated with immotile cilia and flagella, resulting in infertility, chronic respiratory infections, and situs inversus.
Wirschell, M., R. Yamamoto, L. Alford, A. Gokhale, A.R. Gaillard, and W.S. Sale. 2011. Regulation of ciliary motility: conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme. Archives of Biochemistry and Biophysics. Archives of Biochemistry and Biophysics. 510: 93-100.
Evans, S.K., A.A. Pearce, P.K. Ibezim, T.P. Primm, and A.R.Gaillard. 2010. Select acetophenones modulate flagellar motility in Chlamydomonas. Chemical Biology and Drug Design. 75: 333-337.
Wirschell, M., F. Zhao, C. Yang, P. Yang, D. Diener, A.R. Gaillard, J. L. Rosenbaum, and W. S. Sale. 2008. Building a radial spoke: flagellar radial spoke protein 3 is a dimer. Cell Motility and the Cytoskeleton. 65: 238-248.
Gaillard, A.R., L.A. Fox, J.M. Rhea, B. Craige, and W.S. Sale. 2006. Disruption of the A-kinase anchoring domain in flagellar radial spoke protein 3 results in unregulated axonemal PKA activity and abnormal flagellar motility. Molecular Biology of the Cell. 17: 2626-2635.
Gaillard, A. Roush, D. Diener, J. Rosenbaum, and W. Sale. 2001. Radial spoke protein 3 is an A-kinase anchoring protein (AKAP). Journal of Cell Biology. 153: 443-448.